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Diclazepam (also known as chlorodiazepam) is a lesser-known novel depressant substance of the benzodiazepine class. It is a structural analog of diazepam (Valium) and is reported to produce similar effects.

Diclazepam is a novel designer benzodiazepine and a structural analog of diazepam. Diclazepam shows dose-dependent response in alprazolam-trained rats. Diclazepam effect is partially generalized to morphine.

Diclazepam was first synthesized by Leo Sternbach and his team at Hoffman-La Roche in 1960. Diclazepam is not currently marketed as a medication, but rather sold online as a research chemical.

Subjective effects are similar to diazepam and include anxiety suppression, disinhibition, anticonvulsant, hypnotic, muscle relaxing, and amnesia. In animal studies, it has a potency of approximately ten times that of diazepam.[citation needed] Its potency has not been systematically tested in humans, but its closest relatives and two main metabolites are lormetazepam with a potency value of x10-12 of delorazepam which is roughly x10 the potency of diazepam.

It should be noted that the sudden discontinuation of benzodiazepines can be potentially dangerous or life-threatening for individuals using regularly for extended periods of time, sometimes resulting in seizures or death.[6] It is highly recommended to taper one’s dose by gradually lowering the amount taken each day over a prolonged period of time rather than stopping use abruptly, as this can lead to severe, potentially life-threatening withdrawal symptoms.